Tyrphostin AG 879

Research use only, not for human use.

Tyrphostin AG 879 effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.

AG-879 is a tyrphostin compound that inhibits nerve growth factor-dependent TrkA tyrosine phosphorylation in PC-12 cells, HER2-ErbB2 kinase in several breast and ovarian cancer cell lines, and the VEGF receptor FLK1. It decreases cellular proliferation in human muscular sarcoma cell lines.

Cell Proliferation Assay Cell Line:HL-60, U-937, PC-3, HTB-82, HTB-114, TE-671, HTB-115 and HTB-88 cells Concentration:0.5 μM, 5 μM, 20 μM and 50 μM Incubation Time:48 hours Result:Significantly and dose dependently decreased cell proliferation in all the cell lines.Apoptosis Analysis Cell Line:HL-60, U-937, PC-3, HTB-82, HTB-114, TE-671, HTB-115 and HTB-88 cells Concentration:0.5 μM, 5 μM, 20 μM and 50 μM Incubation Time:48 hours Result:Induced a dose-dependent increase in apoptosis.

——

Val-boroPro (mesylate) | PT100 (mesylate)

Angiogenesis

ALK

EGFR| HER2-Neu| PDGFR| Trk

Cancer

——

148741-30-4

316.46

C18H24N2OS

>98% (HPLC)

DMSO : ≥ 30 mg/mL. 94.80 mM

Oc1c(C(C)(C)C)cc(/C=C(\C#N)/C(=S)N)cc1C(C)(C)C

2-Propenethioamide, 3-(3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)-2-cyano-, (E)-

(-20℃)

With Ice Pack

≥ 2 years